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Questa stabilità chimica, già documentata in condizioni acide, rende la via orale una rotta plausibile per la somministrazione nei modelli di ricerca — un'ipotesi supportata da diversi studi preclinici su modelli murini in cui il peptide somministrato oralmente ha mostrato effetti biologici misurabili a livello sistemico e locale nel tratto gastrointestinale

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A change in one marker does not, by itself, establish a broader biological effect or a suitable application outside the conditions of the study